Treating PCOS early may help prevent lower fertility later in life

Adolescent girls with polycystic ovary syndrome (PCOS) who are treated to reduce the amount of abdominal visceral fat and liver fat to normal levels restores ovulation, normalizes the symptoms of hormonal imbalances and may help prevent future fertility problems.

That’s the conclusion of new research from Spain that was presented at ENDO 2017, the annual meeting of the Endocrine Society, in Orlando, Florida.

PCOS is very common among adolescent girls and women. It is a primary cause of female infertility. Researchers studied 36 young women with PCOS who averaged 16 years of age, were non-obese and not sexually active. They had had their first menstruation at least two years before. The women with PCOS had more abdominal and liver fat, higher levels of the hormones androgen and insulin, and markers of poor cardiovascular health.

Participants received either the medication SPIOMET or an oral contraceptive. Those treated with the SPIOMET saw reduced levels of fat, insulin and markers of cardiovascular health. After treatment, these remained more normal in the girls who took SPIOMET than in those on oral contraceptives. And those on SPIOMET had a 2.5-times higher ovulation rate and a 6-times higher prevalence of normal ovulation. The risk of having abnormally few ovulations was reduced 65 percent. The girls who lost the most liver fat ovulated more after treatment.

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