Ibuprofen, the active ingredient in medications like Advil and Motrin, is a common and generally safe pain reliever and anti-inflammatory. But new research published in the journal Proceedings of the National Academy of Sciences found that taking ibuprofen in high doses, as athletes commonly do, resulted in young men developing a hormonal condition known as compensated hypogonadism—shrunken testicles—a condition associated with impaired fertility, along with depression and increased risk for cardiovascular events, including heart failure and stroke.
High-level athletes often take ibuprofen, a non-steroidal anti-inflammatory, before a competition to prevent pain. Researchers studied 31 male volunteers between the ages of 18 and 35. Fourteen were given a high daily dosage of ibuprofen, 600 milligrams twice a day, the maximum limit recommended by generic ibuprofen products.) The others were given a placebo. Within two weeks, the men taking ibuprofen revealed hormonal changes that signified compensated hypogonadism.
If you routinely take high doses of ibuprofen, be sure to discuss this finding with your doctor.