A team of researchers affiliated with multiple institutions in China has used single-cell sequencing to learn more about the human embryo during implantation in the uterus. In their paper published in the journal Nature, the group describes sequencing thousands of human embryo cells from before, during and after implantation, and what they learned from it.
To learn more about what happens during the implantation process, the researchers fertilized 65 human eggs and allowed them to grow in an in vitro culture system. This allowed them to study thousands of cells before, during and after they started the implantation process.
The researchers suggest their work created a path towards better understanding the underlying basis of an array of pregnancy disorders, including recurrent implantation failure, unexplained sporadic and recurrent pregnancy loss and diseases of abnormal placentation.