Recurrent miscarriage linked to chromosomal abnormalities

When a couple loses a pregnancy, and especially when the same couple loses multiple pregnancies, doctors are often at a loss to explain why. For about 40 to 60 percent of couples with recurrent miscarriage (RM), the condition remains unexplained, even after costly testing. Chromosomal abnormalities — rearrangements of large chunks of DNA — in the genomes of one or both individuals trying to conceive are thought to be one of the major genetic causes of RM.

Routine chromosome analysis can currently detect these abnormalities in about 1 in 50 couples. A new study by investigators from Brigham and Women’s Hospital, Shandong University and The Chinese University of Hong Kong uses a special genetic sequencing technique known as low-pass genome sequencing (GS) to look for chromosomal abnormalities in couples with RM. Low-pass GS revealed additional chromosomal abnormalities in more couples than traditional testing, increasing detection to 1 in 9 couples.

The team’s findings were published in The American Journal of Human Genetics.

“RM carries an underappreciated psychological and financial burden for affected couples. It’s often difficult to know how to treat or counsel couples when the cause of their infertility remains unknown,” said co-author Cynthia Morton, PhD, the director of cytogenetics at the Brigham. “There are couples who have chromosomal rearrangements that can’t be seen by classical methods. The technique we’ve used here increases the number of couples who we can detect who are at risk for having miscarriage.”

A technique known as pre-implantation genetic testing (PGT) can help couples with genetic abnormalities conceive through in vitro fertilization. Until now, it’s been unclear which patients with RM would benefit most from genetic testing of their embryos.

“Our results suggest that applying low-pass GS could help identify a larger subgroup of patients at increased risk of subsequent miscarriage who might take advantage of pre-implantation genetic testing,” said Morton.

To learn about our pre-implantation genetic diagnostic services, visit our web site.

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