New mechanism underlying male infertility

The sperm tail is essential for male fertility and thus for sexual reproduction. The tail, or flagellum, has to beat in a very precise and coordinated manner to allow progressive swimming of the sperm. Failure to do so can lead to male infertility.

Researchers in Europe now show that one particular enzymatic modification of a protein called glycylation is essential to keep sperm swimming in a straight line. These findings imply that a disruption of this modification could underlie some forms of male infertility in humans.

Why is this discovery important? “This study points to a new mechanism underlying male infertility,” the authors state.

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Lisa would ‘undoubtedly recommend’ RSCNJ

Lisa, a patient of ours, says:

“I would undoubtedly recommend Dr. Ziegler and his staff. It was hard to leave them once we were pregnant and released to our OB. His staff is so sweet and compassionate. We look forward to going back to them for our next one in a few years!”

Thanks to Lisa, and to all the others who have posted comments on our web site. You can read more of them here.

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Cannabis use may reduce pregnancy chances, study finds

Women who use cannabis products could have a more difficult time conceiving a child than women who do not use marijuana, suggests a study by researchers at the National Institutes of Health.

For each monthly cycle, women who had used cannabis products–marijuana or hashish–in the weeks before pregnancy, or who had positive urine tests for cannabis use, while trying to conceive were 41% less likely to conceive than non-users. Similarly, a smaller proportion of cannabis users than non-users became pregnant during the study–42% versus 66%. The study found no differences in miscarriage rates between users and non-users who had achieved pregnancy.

The authors noted that although the findings suggest cannabis could affect women’s fertility, they should be tempered with caution as the study observed a relatively small number of cannabis users. However, the authors say their results suggest that women trying to conceive should exercise caution with cannabis use until more definitive evidence is available.

The study was published online in Human Reproduction.

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Theresa says RSCNJ is ‘100% recommended!’

Our patient Theresa recently posted comments about her experience at RSCNJ.

“All of the doctors and staff here were efficient, friendly and compassionate. Dr. Ziegler is very knowledgeable. The appointments were always great with little to no wait time. Even calling and speaking to staff over the phone was pleasant. 100% recommend!”

Thanks to Theresa and to all the others who have posted comments on our web site.

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RSCNJ information on the coronavirus vaccine

Many fertility care patients and their families have questions about the coronavirus vaccine–how it works, how safe it is and whether they should get it.

The bottom line is this: Patients undergoing fertility treatment and pregnant patients should be encouraged to receive the vaccination, based on eligibility criteria.

For more detailed information, please go to the special Coronavirus Vaccine Patient Update page on our web site.

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Dr. Ziegler is ‘kind, compassionate, honest and amazing’

Ashley, a recent patient of ours, says this about her treatment at RSCNJ.

“I cannot say enough good things about Dr. Ziegler. He is kind, compassionate, honest and amazing at what he does. He takes his time with us each visit and always has a warm bedside manner. We have a beautiful 6 year old daughter because of Dr. Ziegler and the wonderful staff at the Reproductive Science Center. I would and have recommend anyone to him.”

Thank you Ashley, and thanks to all the patients who posted kind words about their care at RSCNJ. Read more like this at our web site.

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Father’s health a factor in pregnancy loss, study finds

A father who is in bad health before conception may increase the odds for pregnancy loss, a new study in the journal Human Reproduction reports.

Researchers looked at data on 958,804 pregnancies between 2007 and 2016, and correlated that with information on the health of the parents for an average of about four years before conception. They evaluated the fathers’ health based on diagnoses of hypertension, high cholesterol, obesity or diabetes, plus the presence of other common chronic diseases.

Men who had one of these five health factors had a 10 percent increased risk for a partner’s pregnancy ending in loss. Two factors increased the risk by 15 percent, and three or more had a 19 percent increased risk. The age of the mother, along with other maternal and paternal health and behavioral factors, made little difference.

“We need to think about the father even pre-conception,” said Michael L. Eisenberg, an associate professor of urology at Stanford and senior author of the study. “We contribute half the DNA, so it makes sense that that would affect the trajectory of the pregnancy. I want to show that the father is important — fertility is a team sport.”

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Dr. Ziegler ‘helped us become parents-to-be!’

Our patient Kathryn writes, “My husband and I started our journey with Dr. Ziegler in May of this year. Dr. Ziegler and his team made such a difficult process as easy as it could be. He is kind and comforting. We are so thankful for Dr. Z at the Reproductive Science Center for being so caring through such a tough time and helping us to become parents-to-be! We wish we could carry out our whole pregnancy with Dr. Ziegler and will truly miss his compassion! Thank you Dr. Ziegler!”

Congratulations, Kathryn–and thank you for taking the time to post your thoughts about your care here. You can read more reviews like hers at our web site.

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Is this the year you start fertility care?

When you think about your goals for 2021, is one of them to look into seeing a fertility specialist?

When it comes to fertility struggles and the decision to seek professional help, it can be difficult for couples to determine if they are really facing infertility, or if they are experiencing a normal timeframe for achieving pregnancy. Infertility is defined as the inability to become pregnant within 12 months of unprotected sex by couples in which the woman is younger than 35 years of age and has no major medical problems. For couples in which the woman is over 35 years of age, infertility is defined as the inability to become pregnant after six months of unprotected sex.

There are many other situations that might warrant a visit to a specialist. We have much more information on these, and on how to find a reproductive endocrinology and infertility (REI) specialist to assess your specific needs. You can find this information on our web site. Once you do, please give us a call for a free phone consultation.

Make this the year you start your fertility journey. We would be honored to help.

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New podcast: Lifestyle choices and the effect on fertility

It’s estimated that 7.4% of women and their husbands in the United States have a diagnosis of infertility; worldwide, this could be as high as 15%. “But we have to really keep in mind there are some other factors that can affect a patient’s ability to conceive. And one of them is their lifestyle choices or lifestyle factors that can determine their reproductive health and can positively as well as negatively influence fertility.”

So says Dr. William Ziegler, in our latest podcast. Listen to what Dr. Ziegler has to say about lifestyle and fertility in the podcast, below.

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